Médecine

Epigenetic mechanisms (DNA modifications, histone alterations and non-coding RNAs) are crucial for transcriptional regulation and alterations of the “physiological epigenome” are increasingly associated with human diseases. During the last decade the emerging field of neuroepigenomics have started to impact tremendously in areas such learning and memory, addiction or neurodegeneration. This expert volume covers the role of epigenetic molecular mechanism in regulation of central nervous system’s function, one of the most exciting areas of contemporary molecular neuroscience. The book describes the current knowledge on the epigenetic basis of human disease covering the complete lifespan: from neurodevelopment/childhood (Rett Syndrome, Rubinstein-Taybi, autism), adolescence (eating disorders, drug addiction, anxiety), adulthood (depression, schizophrenia, amyotrophic lateral sclerosis, Huntington’s disease) and elderly (Alzheimer’s disease, Parkinson’s disease).
The book also covers the three major players on neuroepigenomic mechanisms: histones alterations, DNA modifications and non-coding RNAs, their roles at the molecular and cellular level and the impact of their alterations on neuronal function and behavior. Finally, a special chapter on state-of-the-art technologies helps the reader not only to understand epigenetic driven changes in human cognition and diseases but also the methodology that will help to generate paradigm shifts on our understanding of brain function and the role of the neuroepigenome in human diseases.

This book is a comprehensive guide to apical periodontitis in root-filled teeth that covers not only all aspects of diagnosis and management but also epidemiology, etiology, consequences, clinical decision-making, and prognosis. There is a particular focus on the available surgical and nonsurgical methods of retreatment designed to restore healthy periapical conditions. Alternatives to retreatment are also explored, including a conservative approach involving monitoring of the diseased tooth without intervention and the option of extraction and replacement with an implant or a fixed prosthesis.
The goal of root canal treatment is to save the natural tooth even when tissue breakdown has resulted in pathological conditions of the pulp and periradicular tissue. However, population studies reveal that complete healing is often absent in root-filled teeth, and apical periodontitis is frequently observed in conjunction with root fillings of poor technical quality. Under these
circumstances, questions arise as to how the apical periodontitis is impacting on the patient and how the condition should be tackled. Readers will find this well-illustrated book to be of great value in directing clinical practice.

This book provides unique insights into the issues that drive modified dosing regimens for antibiotics in the critically ill. Leading international authors provide their commentary alongside a summary of existing evidence on how to effectively dose antibiotics.
Severe infection frequently necessitates admission to the intensive care unit (ICU). Equally, nosocomial sepsis often complicates the clinical course in ICU. Early, appropriate application of antibiotic therapy remains a cornerstone of effective management. However, this is challenging in the critical care environment, given the significant changes in patient physiology and organ function frequently encountered. Being cognisant of these factors, prescribers need to consider modified dosing regimens, not only to ensure adequate drug exposure, and therefore the greatest chance of clinical cure, but also to avoid encouraging drug resistance.

This book offers a comprehensive and clinically relevant survey of adolescent gynecology. Adolescent Gynecology: A Clinical Casebook addresses the many intersecting considerations of gynecologic and reproductive health care for this population using a concise, case-based format.
Organized in four sections, the first introduces chapters on adolescent confidentiality, puberty, and well care. Section II covers varied menstrual disorders, while Section III highlights issues in reproductive health care including sexually transmitted infection and adolescent pregnancy. Finally, Section IV addresses special populations of adolescents, including chapters on girls who have sex with girls, girls who are victims of abuse and girls with special health care needs and chronic health conditions. In each section common gynecologic health issues are discussed in the context of these clinical cases, provide the knowledge needed to further improve comprehensive care of adolescent patients.

This practical manual, written by well-known experts, reviews current indications for the use of IgG concentrates and some other modern immunomodulators and provides fundamental information on present-day immunomodulation in patients (and mice). The book opens by tracing the transition from IgG substitution to IgG immunomodulation and providing expert updates on immunomodulatory indications in autoimmune and inflammatory disorders, including hematologic, neurologic, dermatologic, and other diseases. Basic aspects of IgG concentrates, including methods of production, safety, currently available products, and mechanisms of action, are then discussed. An entire chapter is devoted to the different aspects of immunomodulatory IgG treatment in the bleeding disorder immune thrombocytopenia (ITP). Finally, the transition from polyclonal to monoclonal antibody (mAb) treatment is addressed in detail, covering mAb development, methods, mechanisms of action, adverse effects, and more. Particular attention is paid to the example of anti-CD20 (B-cell) antibody.